Formulation and evaluation of detarium oil based organogel for sustained release of metronidazole via topical delivery

The rationale for this study was to increase the absorption of model drug metronidazole by formulating an organogel using detarium oil in place conventional oils used formulation such as liquid paraffin. organogels were prepared fluid-filled mechanism drug. drug-surfactant mixtures dissolved followed addition water which led formation at specific compositions. formulations analyzed microscopy, rheology, vitro release and X-ray diffraction (XRD). Microscopic studies revealed gels contained clusters water-filled spherical structures. FTIR showed compatibility components organogels. DSC result all released heat during formation. viscosity elastic flow a non-elastic phase. cumulative percentagerelease found be between 63% 85% end 10 h, with OGM 9 having highest release. XRD indicated crystalline nature Metronidazole from dissolution, shape, size, surface area dependent results also good excipients. Sustained successfully developed oil.
 Keywords: Organogel; Detarium oil; Metronidazole; Topical delivery